De Novo Peptide Sequencing with Logistic Regression and Evolutionary Algorithms

Erik Pitzer presents the topic of his PhD thesis. He starts by giving a short, but helpful introduction to the field and continues to explain the functionality of mass spectrometry. The goal in his work is to find a method that allows to make reliable statements regarding the structure of a protein. To achieve this he explains how a Genetic Algorithm can be useful and how it is possible to model the scoring functions, which is perhaps the biggest problem. Finally he presents first results and an outlook for his work.

Download: De Novo Peptide Sequencing.pdf (~600kb; English)